Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli
نویسندگان
چکیده
The formation of complex but highly organized neural circuits requires interactions between neurons and glia. During the assembly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartments in the antennal lobe, each of which represents a discrete olfactory information-processing channel. Each compartment is separated from the adjacent compartments by membranous processes from ensheathing glia. Here we show that Thisbe, an FGF released from olfactory neurons, particularly from local interneurons, instructs ensheathing glia to wrap each glomerulus. The Heartless FGF receptor acts cell-autonomously in ensheathing glia to regulate process extension so as to insulate each neuropil compartment. Overexpressing Thisbe in ORNs or PNs causes overwrapping of the glomeruli their axons or dendrites target. Failure to establish the FGF-dependent glia structure disrupts precise ORN axon targeting and discrete glomerular formation.
منابع مشابه
Correction for Wu et al., Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli.
NEUROSCIENCE Correction for “Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli,” by Bing Wu, Jiefu Li, Ya-Hui Chou, David Luginbuhl, and Liqun Luo, which was first published July 3, 2017; 10.1073/pnas.1706533114 (Proc Natl Acad Sci USA 114:7505–7512). The authors note that an additional affiliation should be listed for Bing Wu. The new affi...
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